Introducing Theropod. A set of python and R tools that I’ve put together to do STORI analysis with an external digital oscilloscope. pubs.acs.org/doi/10.1021/...
Theropod: Software Tools to Analyze Externally Collected Selective Temporal Overview of Resonant Ions pubs.acs.org/doi/10....
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#proteomics #prot-paper
Recent developments in charge detection mass spectrometry have allowed for the broad characterization of individual proteoforms and mixtures of proteoforms from individual ions collected in Orbitrap m...
Introducing Theropod. A set of python and R tools that I’ve put together to do STORI analysis with an external digital oscilloscope. pubs.acs.org/doi/10.1021/...
PastelBio
Tim Cleland
Tim Cleland
pubs.acs.org
Recent developments in charge detection mass spectrometry have allowed for the broad characterization of individual proteoforms and mixtures of proteoforms from individual ions collected in Orbitrap m...
It is true, if anyone is interested in collaborating on some FDR problems let me know. #proteomics
Tim Cleland
You saw it at conferences all over 2025, now my latest construction is published online: a flexible, general-purpose, small molecule MS probe that fits into the tight spaces. (Yes, it's my favorite graphical abstract)
pubs.acs.org/doi/full/10....
Do you need to clean your teeth? And if so, how? 🦷
The answer is YES, at least for Pleistocene teeth. Here, we show you why that is the case, and find a couple of good methods: www.nature.com/articles/s41...
Scientific Reports - Identification and removal of contamination in palaeoproteomic analysis of dental enamel
www.nature.com
A variety of non-proximate mass spectrometry techniques have been implemented to sample organic analytes from distant surfaces, but they frequently risk signal carryover and loss by relying on unheate...
We subsequently developed a charge correction tool to turn improperly calculated charges (from multiple ions measured together, decay of the charge during data collection) into the correct charge value. This correction results in the Gaussian isotopic envelope typical of proteins.
This was a super fun time and it is always nice to talk about paleoproteomics.
We measured single/limited numbers of ions from intact proteins of various sizes including mixtures and applied the STORI slope calculation to calculate the charge.
