This is the culmination of >10 years of work by generations of students and postdocs. Many false starts. And we know that others have tried too.
Structural insights into the activate-and-release mechanism of NLR activation.
And we can engineer it too!
Kudos Team 🙏🔥
Sophien Kamoun
Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade 🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇
Video
Mauricio Contreras
A conserved structural logic underlies sensor-helper NLR communication in the NRC immune receptor network https://www.biorxiv.org/content/10.64898/2026.05.18.725810v1
