Thrilled to announce that the Department of Microbiology at the University of Washington, School of Medicine is hiring at the Assistant Professor level (tenure-track)!
The Pacific Northwest is an awesome place to live and do science 🧪🦠. Join us!
apply.interfolio.com/185622
Applications due 8/1.
Online Now: TRIM21 induces selective autophagy of viruses and bacteria Online now:
Patrick S. Mitchell
Rhinesmith et al. describe an intracellular antimicrobial mechanism called “antibody-directed xenophagy” (ADX). In ADX, the E3 ubiquitin ligase TRIM21 prevents infection by intercepting antibody-coated viruses/bacteria in the cytosol and orchestrating their destruction via selective autophagy. The authors hypothesize that ADX may be co-opted for targeted protein degradation.
Only a couple of days left to register for the UK Cellular Microbiology Network Meeting - we will have a great line up of speakers and poster presenters investigating various pathogens in cell-based, tissue and in vivo models.
Congratulations!
Dual-channel Cx46/50 gap junction assemblies in a shared lipid-nanodisc = lipid-mediated packing and a lipid site near the NT gating region that is absent from single channels. Plus a 1.8 Å open-state single-channel benchmark! #cryo-EM 🍩’s #NIH-funded-research www.biorxiv.org/content/10.6...
