How does your immune system tell pathogenic RNA from your own, even though they’re made of the same stuff?
Our latest paper with @gantierlab.bsky.social shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. 🧬🔬⭐
www.nature.com/articles/s41590-026-02429-2
Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and autoimmunity.
