Inlay

Excellent talks from the Pathway to Stop Diabetes Symposium at #ADA2026. Thank you, Marie-France Hivert, Chelsea Hepler and Tinashe Chikowaore!! @metabologiajnl.bsky.social supports #ECR researchers in #diabetes and #metabolism.

Interesting new study examining the biological mechanisms linking metabolic dysregulation & olfactory impairment #T2D #Obesity #DiabetesResearch

New study on clinical and psychological phenotypes of #T1D and disordered eating derived from a case vignette series: T1DE (#T1DE) phenotypes. Toward unified diagnosis and improved care! link.springer.com/article/10.1... 🔓

Using population data from 4 countries, this study shows younger people with diabetes have ↑ obesity but more favourable renal markers, while blood glucose peaks in mid-life, highlighting complex #age-related risk patterns. #DiabetesComplications #T2D link.springer.com/article/10.1...

Aims/hypothesis Type 1 diabetes and disordered eating (T1DE) is a common, complex comorbidity of type 1 diabetes with high morbidity and mortality risk. T1DE currently lacks a clear definition, diagno...

Aims/hypothesis Beyond longer diabetes duration, uncertainty remains regarding the factors that contribute to a higher risk of developing complications in younger vs older people with type 2 diabetes....

Up front & free to read in our June issue #editorspicks: Atypical diabetes subtypes in Black African populations doi.org/10.1007/s001...

Atypical diabetes subtypes and presentations are disproportionately prevalent in populations of African and Asian ancestry. This review discusses the epidemiology, clinical presentation, aetiopathogenesis and management of four atypical diabetes subtypes commonly reported in Black African populations. These are ketosis-prone diabetes (KPD), fibrocalculous pancreatic diabetes (FCPD), type 2 diabetes in individuals without overweight or obesity, and malnutrition-related diabetes (MRD). The review summarises current insights into these atypical diabetes subtypes in Black African populations and provides practical recommendations to guide their precision diagnosis and management in the African region. These four atypical diabetes subtypes exhibit phenotypic features that diverge from those of classical type 1 and type 2 diabetes. KPD is characterised by unprovoked, transient, index episodes of diabetic ketoacidosis, often in the absence of markers of islet cell autoimmunity, with frequent subsequent insulin independence and diabetes remission. FCPD typically presents in young lean individuals, with a strong male preponderance and with radiological evidence of pancreatic calcifications, reduced beta cell reserve and severe hyperglycaemia without ketosis. Type 2 diabetes in individuals without overweight or obesity is characterised by normal BMI with a trend towards low levels of markers of visceral adiposity, insulin resistance and an exaggerated beta cell secretory dysfunction. MRD is associated with a previous and persistent history of undernutrition, with features of undernutrition such as stunting and BMI <18.5 kg/m2, resistance to diabetic ketoacidosis, no evidence of visceral or ectopic adiposity, and severe beta cell secretory dysfunction. The high prevalence and heterogeneous presentation of these atypical forms of diabetes in African populations highlight the urgent need for enhanced collaborative research to better define their epidemiology, improve diagnostic accuracy and develop context-appropriate management strategies tailored to diverse African populations. Graphical Abstract

#Obesity & #Type2Diabetes can alter the sense of smell and olfactory changes, in turn, influence metabolism. Using evidence from preclinical models🐁🔬, the authors discuss biological mechanisms linking metabolic dysregulation & olfactory impairment link.springer.com/article/10.1... 🔓

Up front & free to read in our June issue #editorspicks: Association of corneal nerve parameters with nerve abnormalities and neuropathic pain in prediabetes and type 2 diabetes: the Maastricht Study doi.org/10.1007/s001...

Up front & free to read in our June issue #editorspicks: Continuous glucose monitoring as a tool in early-stage type 1 diabetes link.springer.com/article/10.1...

Olfaction and its dysfunction have gained increasing interest across a broad spectrum of research areas including ageing and neurodegenerative and psychiatric disorders. In addition, olfactory dysfunc...

👉 Bariatric surgery reduced insulin requirements by 58 % in people with #T1D & #obesity, a study published in Diabetes Care (ADA Journal) showed. However, HbA1c levels were improved only modestly. 📖👉 Read here: easd-elearning.eu/news/472/Typ... #DiabetesResearch #Type1Diabetes #BariatricSurgery

Aims/hypothesis Corneal confocal microscopy is a valuable technique for assessing neuropathy; however, whether it can distinguish painful from painless neuropathy remains uncertain and existing evidence is based on the results of smaller studies. This study assessed the association of corneal nerve parameters with abnormalities identified by electromyography (EMG) and neuropathic pain in a large population with and without (pre)diabetes. Methods In this study we included cross-sectional data for 3425 participants from the Maastricht Study. Wide-field corneal confocal microscopy (WF-CCM) was performed using fully automated analysis of three corneal nerve parameters: corneal nerve branch density (CNBD), corneal nerve fibre density (CNFD) and corneal nerve fibre length (CNFL). An axonal degeneration composite score comprising compound muscle action potential amplitudes (peroneal and tibial) and the sensory nerve action potential amplitude of the sural nerve was created by categorising EMG amplitudes as normal or indicating minor (≤10th percentile), moderate (≤5th percentile) or severe (≤2.5th percentile) abnormalities. Neuropathic pain was determined as a modified Douleur Neuropathique en 4 Questions (DN4) interview score ≥3. Results The mean age of the participants was 59.2 years; 51.6% were female, 15% had prediabetes (defined as impaired fasting glucose, impaired glucose tolerance or both) and 19% had type 2 diabetes. The median diabetes duration was 3.0 years. Regression analyses revealed statistically significant associations between the axonal degeneration EMG score and WF-CCM parameters (CNFL: β=−0.51 [95% CI −0.78, −0.24]; CNFD: β=−1.56 [95% CI −3.04, −0.08]; CNBD: β=−3.08 [95% CI −5.51, −0.64]; all p<0.05) but no statistically significant associations between neuropathic pain and WF-CCM parameters (CNFL: β=−0.06; CNFD: β=−1.15; CNBD: β=−0.22; all p>0.1). Conclusions/interpretation The study found associations between the axonal degeneration EMG score and WF-CCM, but no associations were observed between neuropathic pain and WF-CCM parameters, suggesting that WF-CCM has limited value in assessing neuropathic pain. Graphical Abstract

Continuous glucose monitoring (CGM) has transformed diabetes management by providing continuous, real-time insights into glucose dynamics, while enhancing the lived experience of individuals with type...

🎉 Our latest review is out in @diabetologiajnl.bsky.social ! We dive into the bidirectional link between #Obesity ⚖️, #Type2Diabetes 🩸, and #Olfaction 👃, and its relevance for metabolic health 🩺 🍽️. Kudos to @janice-bulk.bsky.social and @lcreimon.bsky.social for their work! 👏 rdcu.be/flCUK

📺 Join EiC Dr. Jennifer Sargent & Assoc. Editor Dr. Simon Dreher for a webinar introducing EASD’s new journal, @metabologiajnl.bsky.social. Learn about its vision, submissions, & editorial opportunities for early-career researchers. 📅 2 July 2026 | 🕛 16:00 CEST 🔗👉 us06web.zoom.us/webinar/regi...

European Association for the Study of Diabetes