Biology professor at Bowdoin College. Genetics, flies, chromosomes, weird science đŸ¥°
Jack Bateman
Loading...
Loop extrusion creates rare, long-lived encounters underlying enhancer-promoter communication www.biorxiv.org/content/10.1...
Non-Mendelian inheritance of DNA methylation patterns in mice www.nature.com/articles/s41...
Jack Bateman
How does the piRNA pathway solve the self vs. non-self problem? đŸ§¬
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
Davidovich et al. investigate allele-specific DNA methylation inheritance patterns in mouse liver and muscle. Most patterns are Mendelian, but ~7% are non-Mendelian, including new imprinted genes and ...
This is really amazing- analysis of ~5000 year old DNA identifies a father and son that were buried 140 miles apart. I cannot think of the odds of observing this www.science.org/doi/10.1126/...
How do pairs of DNA loci - such as enhancers and promoters - find each other inside the nucleus? đŸ¤”
Most models assume the random forces driving locus motion are independent in space
New preprint by
@janniharju.bsky.social: this assumption fails in living cells đŸ§µ
www.biorxiv.org/content/10.6...
We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ
link.springer.com/article/10.1...
Dominik Handler
Diving into evolutionary biology! What is the origin of the most abundant class of insect transcription factors, ZAD-ZnFs? We suggest that they evolved from ancestral insulator-binding proteins that control 3D genome topology.
www.science.org/doi/10.1126/...
Is distal gene activation by enhancers inherently different from promoter-proximal activation? We propose not. But both cohesin and cooperativity are important aspects of how transcription is affected. Happy to share our recent preprint (thread below) 1/
www.biorxiv.org/content/10.6...
Craig Kaplan
This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? đŸ˜¬
Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles
By @timothyfoldes.bsky.social đŸ’»& @karissalhansen.bsky.social đŸ§ª
đŸ§µđŸ‘‡
