Are infraslow oscillations the missing link between sleep and Alzheimer's? https://www.biorxiv.org/content/10.64898/2026.04.09.717425v1
bioRxiv Neuroscience
Happy to share our recent theoretical review
Why do we sleepwalk? A noradrenergic hypothesis of NREM sleep parasomnias
www.sciencedirect.com/science/arti...
Brain and Sleep Research Laboratory
Latest piece of the lab. We studied the effects of vestibular stimulation during sleep on synaptic plasticity and motor learning.
Rocking-induced sleep enhancement promotes motor learning through transcriptional and synaptic remodelling
rdcu.be/e8Paq
Brain and Sleep Research Laboratory
At the cellular level, sleep loss triggered ER stress and lipid dysregulation in oligodendrocytes, with a key role for cholesterol homeostasis in myelin.
In rats, chronic sleep loss caused thinner myelin sheaths and slower interhemispheric signal conduction, measured directly in vivo.
📌 Take-home: Sleep is essential for myelin maintenance. Disrupted oligodendrocyte function may underlie cognitive and behavioral impairments after sleep loss.
💡 Enhancing cholesterol redistribution to myelin prevented conduction delays and behavioral deficits, despite ongoing sleep loss.
Using human MRI data and animal models, we found that poor sleep quality is associated with widespread reductions in white matter integrity.
Brain and Sleep Research Laboratory
Brain and Sleep Research Laboratory
🧠💤 New lab paper in @pnas.org
Sleep loss doesn’t just make neurons tired - it slows the communication between them.
We show that chronic sleep loss impairs myelin integrity, slows neural signal conduction, and affects cognition & motor behavior.
👉 www.pnas.org/doi/10.1073/...
🙏 Huge thanks to all co-authors for an amazing collaborative effort!
