🚨Paper Alert!
Check out our latest work, now published in @FrontiersNeuroscience. We show how this remarkable fish surprisingly displays mammalian-like injury responses after optic nerve transection.
🔗 doi.org/10.3389/fnin...
@JulieDeSchutter @StevenBergmans @lucamasin.bsky.social @AnyiZhang
Even more intriguing: the retinal ganglion cells in killifish retain their intrinsic growth potential. 🧐
However, instead of navigating towards the brain, they misdirect and loop within the retina (yellow arrowheads).
Adult killifish — both young and old — fail to reinnervate their brain target after complete optic nerve transection. 🐠🧠👁️
This is surprising, as most teleost fish are able to fully restore neural circuitry and regain visual function after this type of injury.
Why does this happen? 🔎 A gliofibrotic scar forms at the injury site, an injury response typically associated with mammals.
So the axons keep growing, but they physically and chemically can’t overcome the barrier. The result: permanent vision loss.
To reduce the extensive scarring, we performed a partial optic nerve transection in young adults, leaving a portion of the nerve uninjured.
This approach indeed limited scar formation, and it allowed regenerating axons to reach the brain and reinnervate their targets. ✅
With transcriptomic and functional data, @lucamasin.bsky.social et al. @labmoons.bsky.social show that local glycolysis supports injury-induced axonal regeneration. rupress.org/jcb/article/...
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
A new preprint from our lab is out! 🥳 Congrats to Anyi Zhang and @lucamasin.bsky.social for this great paper titled: Repressed mTORC1 signaling and transient dendritic pruning support axonal regeneration! Grateful for the fruitful collaboration with the @filodelbene.bsky.social and Poulain labs!
doi.org
Adult mammals exhibit limited regenerative capacity in the central nervous system (CNS), leading to irreversible deficits following injury or disease. Effect...
📚Take-home message: Axonal regeneration is more than growth. It’s also about the cellular environment.
Want to find out more? doi.org/10.3389/fnin...
Journal of Cell Biology
🚨New preprint out!🚨
I’m excited to share the latest work by Anyi Zhang and me, which shows that mTORC1-dependent transient dendritic pruning is essential for efficient axonal regeneration in spontaneously regenerating zebrafish neurons.
www.biorxiv.org/content/10.6...
Don't miss this amazing meeting in Austria!!! Deadline to register is May 20, 2026!
#EMBORegeneration2026
doi.org
Adult mammals exhibit limited regenerative capacity in the central nervous system (CNS), leading to irreversible deficits following injury or disease. Effect...
The registration deadline for #EMBORegeneration2026 is approaching: May 20 !!! Don't miss this amazing meeting on the banks of the Danube in Austria: meetings.embo.org/event/26-tis...
