Homocysteine disrupts lysosomal function by V-ATPase inhibition. From Yang Yang, Qianjin Kong, Chaolian Liu, Mei Yang, Chonglin Yang and colleagues: rupress.org/jcb/article/...
📕 Part of #Lysosomes 2026: rupress.org/jcb/collecti...
📣 new preprint multimodal atlas. Imaging + scRNA, 57M cells. 🧬🔬
Cells are complex dynamical systems — but most ways we measure them destroy them. We asked: how does live imaging compare to scRNA-seq, the field’s gold std?
The answer surprised us 🧵
www.biorxiv.org/content/10.6...
@julius-w.bsky.social @jclandoni.bsky.social @sulianamanley.bsky.social et al reveal that perinuclear #mitochondria form a source population, w/ biased anterograde transport spreading material to maintain network connectivity & balanced mitochondrial mass across the cell rupress.org/jcb/article/...
A graph neural network framework enables individualized genetic risk prediction at the single-cell level go.nature.com/3H6pAlr
rdcu.be/fmbnx
Drp1 is "browsing" mitochondria to find constriction sites... love that!
The Collaborative Research Network is built on team science.
A new Alzforum article highlights how CRN investigators are working across institutions and disciplines to advance #Parkinson’s disease research through shared tools, data, and expertise.
Read more: bit.ly/4dj8ePI
📢 We are looking for a Junior Group Leader to join us at @institutcurie.bsky.social!
Having joined the department just over a year ago, I can honestly say that it is an exceptionally stimulating and supportive scientific environment, filled with outstanding colleagues — all in the heart of Paris.
Video
I made a video summary of our recent paper on mitochondrial trafficking. 🔬🧫🧬Check out the paper here: doi.org/10.1083/jcb....
@jclandoni.bsky.social @sulianamanley.bsky.social @jcb.org
youtu.be/Az8xzdO0nVU?...
#mitochondria #imaging #fluorescence #organelle
Interactome mapping has been stuck at a few hundred baits over months. HIP-MS changes the regime: ~10,000 pulldowns/week at 500 samples/day, fully automated. A new era for interactomics — and a precursor to high-throughput proteomics writ large. 📄 doi.org/10.64898/202...
A graph neural network framework enables individualized genetic risk prediction at the single-cell level.
Wow! Researchers highlight clear ultrastructural differences between somatic & neuritic αSynpS129 pathology & they demonstrate the structural complexity & heterogeneity of Lewy pathology in postmortem brain from people with #Parkinsons
www.nature.com/articles/s41...
Although protein-protein interactions govern virtually all cellular processes, systematic interactome mapping by affinity enrichment mass spectrometry (AE-MS) is constrained by manual sample preparati...
doi.org
Felix Kraus
Mann Lab
Lara Krüger
Aligning Science Across Parkinson's
Julius Winter
The Science of Parkinson's
We present MitoScanner: a newly discovered step in mitochondrial division! 🔍✂️ Explore here the work by @office-garcia.bsky.social 📝 www.biophys.mpg.de/2921124/sear...
#Mitochondria #CellBiology
