RESEARCH |
@ocoleman.bsky.social , Sorbie, Haller et al. (TUM)
ATF6 causes an enrichment in long-chain fatty acids in the colon, which contributes to the development of colorectal cancer🧪
The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal cancer in humans and mice, thereby linking endoplasmic reticulum stress responses to lipid metabolism and tumorigenesis.
