Much appreciate the spotlight on our (@adelmanlab.bsky.social) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology
Apoorva Baluapuri
Integrator complex collapse: A mechanistic route to integrated stress response and disease
In a recent Cell article, Baluapuri et al. show that loss of the Integrator (INT) complex activates the integrated stress response via double-stranded RNA from incomplete pre-mRNAs, revealing a link to INT-related neurodevelopmental diseases and potential therapeutic targets.
