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Excited to share our new paper just out in @cp-cellreports.bsky.social We identified a signalling axis by which monocytes can directly impair NK cell cytotixocity in #metastasis. Led by @ChristosErmogenous and supported by a great team effort @qmbci.bsky.social www.cell.com/cell-reports...
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Ermogenous et al. show that monocyte-derived MIF suppresses NK cell activation and cytotoxicity through CXCR4, weakening immune control of metastatic seeding in breast cancer. MIF inhibition reverses ...
www.cell.com
MIF mediates monocyte-dependent inhibition of natural killer cell cytotoxicity in triple-negative breast cancer
Luigi Ombrato