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Metastatic Niche Lab @QMBCI.bsky.social. Studying the role of Tumour Microenvironment in Metastasis formation. @CancerResearchUK.org Fellow. Previously at @Crick.ac.uk, @CRG.eu and @TIGEM.bsky.social
Luigi Ombrato
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Excited to share our new paper just out in @cp-cellreports.bsky.social We identified a signalling axis by which monocytes can directly impair NK cell cytotixocity in #metastasis. Led by @ChristosErmogenous and supported by a great team effort @qmbci.bsky.social www.cell.com/cell-reports...
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Ermogenous et al. show that monocyte-derived MIF suppresses NK cell activation and cytotoxicity through CXCR4, weakening immune control of metastatic seeding in breast cancer. MIF inhibition reverses ...
www.cell.com
MIF mediates monocyte-dependent inhibition of natural killer cell cytotoxicity in triple-negative breast cancer
We have an exciting project about radiotherapy and metastasis !!
Luigi Ombrato
Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...