Cell Biologist and microscopist. My lab
@NCIResearchCtr focuses on mitochondria, metabolism, and liver cancer. Views are my own #cellbiology #microscopy
@PoratShliomLab
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Thank you, @bpodaily.bsky.social, for highlighting our research at the Intramural Program of the National Cancer Institute!
#NCI #NIH #LiverZonation #lipid #mitochondria
Huge thanks to @marcliesa.bsky.social and Jessica Segalés for covering our work in this insightful News & Views — we really appreciate the thoughtful perspective and context you brought to the study!
www.nature.com/articles/s42...
@PoratShliomLab
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
@PoratShliomLab
The primary cilium functions as a non-redundant signaling compartment essential for GLP-1R action in islet beta cells www.sciencedirect.com/science/arti...
Juan C. Landoni
Daniel Drucker
Nature Metabolism
Nature Metabolism
Latest published research on #Mitochondria in #Health and #Disease! 📚 #week13
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
PLIN5 phosphorylation orchestrates mitochondria lipid-droplet coupling to control hepatic lipid flux and steatosis
#Therapies for #mitochondrial #disorders community.
You are welcome to join by commenting below!
go.bsky.app/BnMQq9C
#therapy #mitochondria #mitochondrialdisease
By determining the organellar topology and proteome of fat-oxidizing and fat-synthesizing hepatocytes, Kang et al. show that perilipin 5-mediated mitochondria–lipid droplet contacts facilitate the exp...
How hepatocytes cope with surges in dietary fatty acids revealed – role for PLIN5 phosphorylation => possible liver disease treatment target
📷 Sun Woo Sophie Kang et al @poratshliomlab.bsky.social
in @natmetabolism.nature.com
➡️ bpod.org.uk/archive/2026... with
@antdlewis.bsky.social
Nature Metabolism, Published online: 23 March 2026; doi:10.1038/s42255-026-01483-2By determining the organellar topology and proteome of fat-oxidizing and fat-synthesizing hepatocytes, Kang et al. show that perilipin 5-mediated mitochondria–lipid droplet contacts facilitate the expansion of lipid droplets in both populations and are impaired in early metabolic dysfunction-associated steatotic liver disease (MASLD).
Nature Metabolism, Published online: 23 March 2026; doi:10.1038/s42255-026-01476-1Using single-cell tissue imaging and spatial proteomics to study mitochondria–lipid droplet coupling in hepatocytes, PLIN5 phosphorylation is identified as a mediator of lipid flux and nutrient stress responses.
