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A lncRNA packaged in exosomes induces epigenetic reprogramming to alter future immune responses - pretty cool way of "͏𝚒͏𝚗͏𝚗͏𝚊͏𝚝͏𝚎 ͏𝚒͏𝚖͏𝚖͏𝚞͏𝚗͏𝚎 ͏𝚖͏𝚎͏𝚖͏𝚘͏𝚛͏𝚢 ͏𝚝͏𝚛͏𝚊͏𝚗͏𝚜͏𝚖͏𝚒͏𝚜͏𝚜͏𝚒͏𝚘͏𝚗" @cp-cellhostmicrobe.bsky.social www.cell.com/cell-host-mi...
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Yu et al. discover that TRCR1, a tuberculosis resister-derived exosomal lncRNA, induces trained immunity via CLOCK-mediated epigenetic reprogramming. They show that mycobacterial protein MPT53 prompts...
www.cell.com
A CLOCK-targeting lncRNA induces trained immunity against tuberculosis
Alex Lercher