Immunologist | HFSP Postdoctoral Fellow @RiceLaboratory | PhD @bergthalerlab | opinions are my own.
Alex Lercher
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Extremely happy to be awarded the Sidney & Joan Pestka Post-graduate award!
Thank you @cytokinesociety.bsky.social and all my mentors, colleagues and collaborators throughout my career so far!
Alex Lercher
Julia’s paper identifying Aspartate as a determinant cell-state specific engagement of the Malate-Aspartate-Shuttle is now out @cp-molcell.bsky.social!
A lncRNA packaged in exosomes induces epigenetic reprogramming to alter future immune responses - pretty cool way of "͏𝚒͏𝚗͏𝚗͏𝚊͏𝚝͏𝚎 ͏𝚒͏𝚖͏𝚖͏𝚞͏𝚗͏𝚎 ͏𝚖͏𝚎͏𝚖͏𝚘͏𝚛͏𝚢 ͏𝚝͏𝚛͏𝚊͏𝚗͏𝚜͏𝚖͏𝚒͏𝚜͏𝚜͏𝚒͏𝚘͏𝚗"
@cp-cellhostmicrobe.bsky.social
www.cell.com/cell-host-mi...
A commensal bacterium triggers systemic antibody responses via skin lymphoid structures and can be engineered as a topical vaccine – great therapeutic potential!
Two studies in @nature.com.web.brid.gy by the Fischbach and Belkaid labs
tinyurl.com/5yahn47t
tinyurl.com/4n4btxap
Location, infection history, antigen persistence shape the phenotype of tissue-resident T cells (Trm), challenging the idea of a universal framework for Trm identity across organs and diseases.
High/low antigen immunogenicity may add another layer...
@cp-immunity.bsky.social
tinyurl.com/49dkc3j7
Thank you very much #ASciNA and @fwf-at.bsky.social for the ASciNA Young Investigator Award!
Link to publication @cp-immunity.bsky.social : www.cell.com/immunity/abs...
The main function of the TCA cycle is to feed electrons into the respiratory chain.
..wait, what!? It also clears excess citrate, because otherwise you get severe kidney damage?
Great example that textbooks aren’t always the full story by Abby, @juliabrunner.bsky.social and @lydiafinley.bsky.social
Thank you for the member highlight @cytokinesociety.bsky.social and see you all in Seattle for Cytokines 2025!
signals.cytokinesociety.org/2025/09/28/m...
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Innate immune memory is wild 🧠
Alexander Lercher from Rockefeller dives into how cells remember past infections and prep for future ones. Type I interferon doing way more than just fighting viruses!
Full interview: buff.ly/5TKEJ9o
#CytokineSociety #ImmuneMemory #TypeIInterferon #CellsHaveMemoriesToo
Stephanie Flores
A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/
Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent
and can be modulated by the availability of the amino acid aspartate. In differentiated
cells, malate-aspartate s...
Yu et al. discover that TRCR1, a tuberculosis resister-derived exosomal lncRNA, induces
trained immunity via CLOCK-mediated epigenetic reprogramming. They show that mycobacterial
protein MPT53 prompts...
One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...
My name is Alexander Lercher, and I am currently a Postdoc in the lab of Charlie Rice at Rockefeller University in New York, and I am particularly excited about studying immune responses in the context of real-world microbe exposure. Out from the lab, my biggest hobby for the past years has been to explore the
signals.cytokinesociety.org
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the
canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation
and citrate production increa...
The therapeutic potential of antigen-independent innate immune memory (IIM) is of
particular relevance in the context of respiratory viruses with pandemic potential.
Lercher et al. find that antiviral...
My name is Alexander Lercher, and I am currently a Postdoc in the lab of Charlie Rice at Rockefeller University in New York, and I am particularly excited about studying immune responses in the context...
signals.cytokinesociety.org
The International Cytokine & Interferon Society congratulates the winners of the 2025 Sidney & Joan Pestka Graduate and Post-Graduate Awards, the ICIS-Christina Fleischmann Award and the ICIS-Amanda Proudfoot Award. Read more at signals.cytokinesociety.org/2025/07/14/2...
Auszeichnung exzellenter österreichischer Wissenschaftler:innen in den USA: 3 Forschende erhalten heuer #ASciNA Awards für während ihrer Forschungsaufenthalte entstandene Publikationen: Wir gratulieren Caroline Moosmüller, Alexander Lercher u. Gabriele Wadlig! 👏 #BMFWF
www.fwf.ac.at/aktuelles/de...
International Cytokine & Interferon Society (ICIS)
Österreichischer Wissenschaftsfonds FWF
Caroline Moosmüller, Alexander Lercher und Gabriele Wadlig wurden für ihre exzellenten Publikationen mit den ASciNA Awards 2025 ausgezeichnet.
