I'm excited that this collaborative work with Alan @acartmell47.bsky.social is finally out. We have developed some powerful tools to study carbohydrate sulfatases (a tricky class of enzyme!) and shown how they can be used with enzymes from host-associated bacteria.
Great talk by Tessa Gote from the group of @armstrongchembio.bsky.social of the @led3hub.bsky.social at #LeidenBioscience. She talked about the importance of sialic acid esterases for the virulence of S. pneumoniae and how she is working towards developing inhibitors for these enzymes.
Zach Armstrong
Stephan Hacker
Extraordinary opportunity to join as PhD a super network!!!!
Tony Molinaro
The power of sugars. #ERCAdG
I am particularly happy to announce that Ive been assigned an ERC AdG (PE5) to crack the LPS code. thanks to my group!!! @erc.europa.eu
Tony Molinaro
Happy to have this collaborative work with Zach Armstrong now out in Angewandte chemie doi.org/10.1002/anie... .
We use a linked assay, coupled with fluorescent probes, to analyse mucin active carbohydrate sulfatase kinetics, cellular location, and inhibition.
doi.org
We report plate-based coupled assays to rapidly and quantitatively determine the activity and selectivity of mucin-active carbohydrate sulfatases. This fluorogenic assay further enables inhibitor ide...
