Nature research paper: Focal white matter lesions drive grey matter inflammation and synapse loss
go.nature.com/3Qgd47r
go.nature.com
A transient grey matter microgliosis is required for remyelination, the failure of which results in a chronic neuroinflammatory state seen in neurodegenerative disorders.
What happens to the brain after focal myelin loss? Our new paper, published today in @nature.com tries to answer this question: go.nature.com/3Qgd47r
Details in the 🧵 (1/8)
Nature
go.nature.com
Thóra Káradóttir Lab
New atlas shows how adult brain cells retain traces of their development. 🧪
“For this #SingleCell #epigenomic mapping of the human brain, extensive #DNAsequencing was required,” says @gocastelobranco.bsky.social
More here ↓
www.scilifelab.se/news/new-atl...
A new study from Karolinska Institutet and SciLifeLab presents a detailed map of how gene activity is regulated in individual cells of the adult human brain and spinal cord. Published in Nature Neuros...
and my soundtrack for the last part of the ride
Lykke Li's Lucky Again
youtu.be/6OO49j8nSZ8?...
KI researchers have created a detailed map showing how genetic activity is controlled in individual cells of the adult human #brain and #spinalcord. Oligodendroglia retain an epigenetic memory of developmental programs long after these genes are no longer active 🧪 news.ki.se/new-map-reve...
youtu.be
Researchers at Karolinska Institutet have created the first detailed map showing how genetic activity is controlled in individual cells of the adult human brain and spinal cord. The study, published i...
Come and start your group at @ki.se!
ki.se/en/about-ki/...
Karolinska Institutet continues to grow a global community of excellence. In summer 2026, KI is inviting applications for 21 Assistant Professor positions in medicine and health. We are once again loo...
with @deckardw.bsky.social @carlstrom.bsky.social and many others at @ki.se and many collaborators as @mardzix.bsky.social @annawilliamslab.bsky.social & others Thanks for the support @kawresearch.bsky.social @erc.europa.eu @vetenskapsradet.bsky.social etc, & @dyaradhes.bsky.social for👇
Gonçalo Castelo-Branco
Video
Gonçalo Castelo-Branco
Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs!
www.nature.com/articles/s41...
Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs!
www.nature.com/articles/s41...
We got the cover of @natneuro.nature.com April issue for Mukund's article!
Gonçalo Castelo-Branco
Gonçalo Castelo-Branco
www.nature.com
Single-nucleus epigenomic maps of the adult human brain and spinal cord reveal that adult oligodendroglia retain developmental chromatin patterns, suggesting a molecular memory that may shape repair p...
Single-nucleus epigenomic maps of the adult human brain and spinal cord reveal that adult oligodendroglia retain developmental chromatin patterns, suggesting a molecular memory that may shape repair p...
