Professor of Glial Cell Biology @ Karolinska Institutet, Stockholm, Sweden • epigenomics • single-cell • spatial • oligodendrocytes • myelin • multiple sclerosis • 🎧 Hannes • https://ki.se/en/people/goncalo-castelo-branco
Gonçalo Castelo-Branco
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Come and start your group at @ki.se!
ki.se/en/about-ki/...
Nature research paper: Focal white matter lesions drive grey matter inflammation and synapse loss
go.nature.com/3Qgd47r
What happens to the brain after focal myelin loss? Our new paper, published today in @nature.com tries to answer this question: go.nature.com/3Qgd47r
Details in the 🧵 (1/8)
New atlas shows how adult brain cells retain traces of their development. 🧪
“For this #SingleCell #epigenomic mapping of the human brain, extensive #DNAsequencing was required,” says @gocastelobranco.bsky.social
More here ↓
www.scilifelab.se/news/new-atl...
KI researchers have created a detailed map showing how genetic activity is controlled in individual cells of the adult human #brain and #spinalcord. Oligodendroglia retain an epigenetic memory of developmental programs long after these genes are no longer active 🧪 news.ki.se/new-map-reve...
and my soundtrack for the last part of the ride
Lykke Li's Lucky Again
youtu.be/6OO49j8nSZ8?...
We got the cover of @natneuro.nature.com April issue for Mukund's article!
with @deckardw.bsky.social @carlstrom.bsky.social and many others at @ki.se and many collaborators as @mardzix.bsky.social @annawilliamslab.bsky.social & others Thanks for the support @kawresearch.bsky.social @erc.europa.eu @vetenskapsradet.bsky.social etc, & @dyaradhes.bsky.social for👇
Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs!
www.nature.com/articles/s41...
Karolinska Institutet continues to grow a global community of excellence. In summer 2026, KI is inviting applications for 21 Assistant Professor positions in medicine and health. We are once again loo...
A transient grey matter microgliosis is required for remyelination, the failure of which results in a chronic neuroinflammatory state seen in neurodegenerative disorders.
A new study from Karolinska Institutet and SciLifeLab presents a detailed map of how gene activity is regulated in individual cells of the adult human brain and spinal cord. Published in Nature Neuros...
Single-nucleus epigenomic maps of the adult human brain and spinal cord reveal that adult oligodendroglia retain developmental chromatin patterns, suggesting a molecular memory that may shape repair p...
Researchers at Karolinska Institutet have created the first detailed map showing how genetic activity is controlled in individual cells of the adult human brain and spinal cord. The study, published i...
Our April issue is now live!
www.nature.com/neuro/volume...
Our latest in @natneuro.nature.com, lead by Mukund Kabbe, providing single cell epigenomic maps of the human brain and spinal cord with snATAC and our NanoCUT&Tag and finding epigenetic memory in oligodendroglia of developmental programs!
www.nature.com/articles/s41...
Single-nucleus epigenomic maps of the adult human brain and spinal cord reveal that adult oligodendroglia retain developmental chromatin patterns, suggesting a molecular memory that may shape repair p...
