Our paper is out today!!! (not an April fool's day joke) Congrats to authors @azulsilva.bsky.social, @belalima-paiva.bsky.social, Ele Pronier, and mostly to the amazing scientist and human being who led this project @facuumm.bsky.social
#neuroskyence #hippocampus
www.nature.com/articles/s41...
Spread the voice 📣
Join us on Nov 18 for an online webinar on science outreach!
Hear from researchers, journalists, and science communicators about how to share science effectively with diverse audiences.
@elife.bsky.social @hfspo.bsky.social @embo.org
#ScienceCommunication #SciOutreach #Webinar
After nine years, I’m very happy to finally publish the last paper from my PhD.
A huge thank you to members of my former team who helped make this possible. Now it’s time to think about new projects and keep doing science together.
pubs.acs.org/doi/10.1021/...
#neuroscience #serotonin #memory
Synchronization of sharp-wave ripples across the dorsoventral hippocampus during sleep supports coordinated reactivation that represents negative experiences more faithfully than positive ones.
The acquisition of temporally proximate information can impair the brain’s ability to consolidate earlier experiences, resulting in retroactive interference (RI). Recognition-based behavioral paradigms are well-suited for investigating RI in rodents, particularly those involving sequential learning episodes. The medial prefrontal cortex (mPFC) integrates multimodal information relevant to the regulation of memory interference and is strongly modulated by the serotonergic system. Serotonin 2A receptors (5-HT2AR), which are densely expressed in the mPFC, have been shown to influence the retrieval of competing object-recognition memories. However, their role in other phases of memory processing, particularly in modulating RI, remains unclear. Using a modified version of the object recognition task designed to induce RI, combined with pharmacological manipulation of 5-HT2AR, we demonstrate that RI specifically impairs the object-related component of memory. Moreover, serotonin signaling through 5-HT2AR is necessary to prevent RI. Strikingly, activating 5-HT2AR before retrieval can rescue the expression of memories affected by RI, suggesting that RI may not erase memory traces but rather hinder their access.
pubs.acs.org
Check out my preprint on hippocampal ripple diversity, with @vitorlds.bsky.social and David Dupret at the MRC BNDU, where we reveal that distinct CA1 laminar profiles of ripples are associated with different reactivation dynamics: www.biorxiv.org/content/10.1...
📢 Spread the word!
Tomorrow at the Paris Postdoctoral Seminar (IBPS), Marie Sion will present her work on the mechanisms underlying transplant rejection.
🕚 11:00 — Room C404, Building C, Campus Pierre et Marie Curie.
@ibps.bsky.social @parispostdocs.bsky.social
Spread the word! 🗣️🎙️
Together with @azulsilva.bsky.social and Bluesky-less Magdalena Miranda, supported by @elife.bsky.social, we’re organizing a webinar bringing together people working in science communication and outreach.
Please, feel free to share the flyer with anyone who might be interested!
Tomorrow @parispostdocs.bsky.social
We are pleased to host another edition of the Paris Postdoctoral Seminar tomorrow at the @ibps.bsky.social .
We will welcome Sheryl BUI from Université Paris Cité.
Room C404, at 11:00 am
Campus Pierre et Marie Curie, Building C, 4th Floor
☕ Interested in chatting with the speaker or meeting IBPS postdocs & PhD students?
Join us for coffee at 10:30, in the same room.
