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Professor at Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College. My lab is interested in immune responses against cancer and infection. https://www.mskcc.org/research/ski/labs/joseph-sun
Joseph Sun Lab









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Remembering Eva…
Greetings from Stockholm. We celebrated the 50th year anniversary of NK cells, and the legacy of Eva and George Klein… in the Klein lecture hall at the Karolinska Institute! Historical tributes and entertaining stories from Hans Wigzell, Rolf Kiessling, Klas Karre, Wayne Yokoyama, and Lewis Lanier!!
Working with rare immune populations? We describe an optimized low-input ATAC-seq workflow for tissue ILCs, allowing for reproducible epigenetic profiling. Technical report now out at EJI @EurJImmunol: onlinelibrary.wiley.com/doi/10.1002/.... Have a look!
Have a look at this new study by Dr. Celeste Dang in @natimmunol.nature.com showing an interesting new role for the transcription factor TCF19 in driving antiviral NK cell function. Congrats Celeste for driving this one to the finish line! @mskcancercenter.bsky.social
Congratulations to DR. Celeste Dang on a fantastic thesis talk and successful defense!! @mskeducation.bsky.social
Here’s a more official (but far less creative) flyer from the GSK graduate school @mskcancercenter.bsky.social
These curious-looking flyers appeared in our hallways this week! They announce Celeste Dang’s thesis defense on Monday. Good luck Celeste!!
Wonderful to catch up with two former @wcm-imp.bsky.social grad students at this @faseborg.bsky.social meeting! So proud of alum who are now faculty running their own labs- Priya Issuree (U Iowa) and Ruth Franklin @ruthfranklinlab.bsky.social (Harvard). Nothing makes a program director more happy!
Check out this new study and TCR Tg mouse generated by Endi Santosa @endicytosis.bsky.social. If you are interested in studying classic and inflationary CD8+ T cell memory to MCMV infection, we’re happy to share this mouse, and @laboxenius.bsky.social is extremely generous with her Tg lines as well.
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May 20, 2025
(1/2) In a study published in @cp-immunity.bsky.social, MSK's @josephsunlab.bsky.social and Dr. Rebecca Delconte found that fasting can supercharge the immune system's “natural killer” cells, a type of white blood cells that can kill #cancer cells.
Assessing chromatin accessibility in rare cell populations within tissue remains a key challenge. To address this, we present a low-input ATAC workflow optimized for liver ILCs. The protocol is valid...
onlinelibrary.wiley.com
Low‐Input Assay for Transposase‐Accessible Chromatin Identifies Epigenetic Signatures of Liver Group 1 Innate Lymphoid Cells
Sun and colleagues report that the transcription factor TCF19 regulates calcium signaling and cell cycling progression in NK cells and is required for innate and adaptive NK cell responses to viral in...
www.nature.com
TCF19 drives a broad transcriptional program that potentiates optimal innate and adaptive functions of antiviral NK cells - Nature Immunology
Our findings reveal a divergent transcriptomic and epigenetic landscape between conventional and inflationary memory responses in spleen and liver during l
rupress.org
Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection | Journal of Experimental Medicine | Rockefeller University Press
Apr 18, 2025
Joseph Sun Lab
Joseph Sun Lab
Gabriela Wiedemann Lab
Joseph Sun Lab
Joseph Sun Lab
Joseph Sun Lab
Joseph Sun Lab
Joseph Sun Lab
Joseph Sun Lab
Memorial Sloan Kettering Cancer Center