PKCα-mediated nuclear translocation of cGAS stabilizes β-catenin and drives metastasis: Molecular Cell www.cell.com/molecular-ce...
www.nature.com/articles/s41...
journals.sagepub.com/doi/10.1177/...
We, @easdnews.bsky.social & @amdiabetesassn.bsky.social are requesting public commentary on the 2026 Consensus Report on the Management of #Type2Diabetes.
📅 Review the symposium slides & submit your input before 11:59 pm ET (17:59 CEST) on 16 June 2026.
🔗 professional.diabetes.org/clinical-sup...
www.neurology.org/doi/10.1212/...
www.frontiersin.org/journals/mol...
Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling: Cell Metabolism www.cell.com/cell-metabol...
DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function: Cell Metabolism www.cell.com/cell-metabol...
Mitochondria-lysosome coupling contributes to lysosome acidification and aging: Molecular Cell www.cell.com/molecular-ce...
Therapy and biomarker dependent progression-free survival in infant sonic hedgehog medulloblastoma: a multi-national retrospective cohort study - eClinicalMedicine www.thelancet.com/journals/ecl...
Zhang et al. reveal that nuclear cGAS promotes breast cancer metastasis by stabilizing
β-catenin independently of STING. PKCα-mediated phosphorylation drives cGAS nuclear
entry, where it prevents TRIM...
www.cell.com
npj Primary Care Respiratory Medicine - AI-driven clinical decision support for early diagnosis and treatment planning in patients with suspected sleep apnea using clinical and demographic data...
Background Individuals with difficult-to-treat migraine, including resistant migraine (ResM) and refractory migraine (RefM), might experience treatment delays, ...
journals.sagepub.com
Background and ObjectivesAnti–Kelch-like protein 11 (KLHL11) encephalitis was discovered in middle-aged men
with testicular seminoma and rhombencephalitis, defining a new type of paraneoplastic
neurol...
Lactate, traditionally regarded as a metabolic byproduct of glycolysis, is now recognized as a critical signaling molecule in the central nervous system. Eme...
Suzuki and Yoshioka et al. show that the garlic-derived metabolite S-1-propenyl-L-cysteine
(S1PC) increases circulating eNAMPT, a key NAD+ biosynthetic enzyme, in mice and humans
by activating a criti...
Through comprehensive phenotyping of complex mouse models and in vitro studies, the
authors uncovered that futile lipid cycling has a sizable thermogenic output. However,
in its absence, alternative m...
www.cell.com
While classical models propose that lysosomes/vacuoles are acidified using free cytosolic
protons, Liu et al. reveal that mitochondrial electron transport provides a substantial
proton source through ...
Our findings show that iMBSHH outcomes and prognostic biomarkers are therapy dependent.
In our retrospective patient group, non-metastatic iMBSHH treated with high-dose or
IVT-MTX chemotherapy-only ha...
