"Science isn't just a job, it's the passion for transforming knowledge into impact."
Physician š·ļø Academic š·ļø Clinical Biomedical & Translational Research š·ļøMedical & Scientific Writing š·ļø Consultant š·ļø Amateur astronomer.
#MedSky #SciSky #BioChemSky
IvĆ”n DarĆo Bravo Tobar. M.D. | M.Sc. | Ph.D.
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Mitochondria-lysosome coupling contributes to lysosome acidification and aging: Molecular Cell www.cell.com/molecular-ce...
www.nature.com/articles/s41...
journals.sagepub.com/doi/10.1177/...
DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function: Cell Metabolism www.cell.com/cell-metabol...
www.frontiersin.org/journals/mol...
Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling: Cell Metabolism www.cell.com/cell-metabol...
PKCĪ±-mediated nuclear translocation of cGAS stabilizes Ī²-catenin and drives metastasis: Molecular Cell www.cell.com/molecular-ce...
While classical models propose that lysosomes/vacuoles are acidified using free cytosolic
protons, Liu et al. reveal that mitochondrial electron transport provides a substantial
proton source through ...
npj Primary Care Respiratory Medicine - AI-driven clinical decision support for early diagnosis and treatment planning in patients with suspected sleep apnea using clinical and demographic data...
Through comprehensive phenotyping of complex mouse models and in vitro studies, the
authors uncovered that futile lipid cycling has a sizable thermogenic output. However,
in its absence, alternative m...
Therapy and biomarker dependent progression-free survival in infant sonic hedgehog medulloblastoma: a multi-national retrospective cohort study - eClinicalMedicine www.thelancet.com/journals/ecl...
IvĆ”n DarĆo Bravo Tobar. M.D. | M.Sc. | Ph.D.
Lactate, traditionally regarded as a metabolic byproduct of glycolysis, is now recognized as a critical signaling molecule in the central nervous system. Eme...
Suzuki and Yoshioka et al. show that the garlic-derived metabolite S-1-propenyl-L-cysteine
(S1PC) increases circulating eNAMPT, a key NAD+ biosynthetic enzyme, in mice and humans
by activating a criti...
Zhang et al. reveal that nuclear cGAS promotes breast cancer metastasis by stabilizing
Ī²-catenin independently of STING. PKCĪ±-mediated phosphorylation drives cGAS nuclear
entry, where it prevents TRIM...
Our findings show that iMBSHH outcomes and prognostic biomarkers are therapy dependent.
In our retrospective patient group, non-metastatic iMBSHH treated with high-dose or
IVT-MTX chemotherapy-only ha...
Background and ObjectivesAntiāKelch-like protein 11 (KLHL11) encephalitis was discovered in middle-aged men
with testicular seminoma and rhombencephalitis, defining a new type of paraneoplastic
neurol...
We, @easdnews.bsky.social & @amdiabetesassn.bsky.social are requesting public commentary on the 2026 Consensus Report on the Management of #Type2Diabetes.
š Review the symposium slides & submit your input before 11:59 pm ET (17:59 CEST) on 16 June 2026.
š professional.diabetes.org/clinical-sup...
