And interestingly, ProRS values in the disease population are elevated even a decade before diagnosis! These scores then continue to rise up until diagnosis.
It'll be interesting to see how proteomics will continue to grow to help identify disease states and its application for precision medicine
While proteomic risk scores (ProRS) provide a dynamic look at a person's current health status, polygenic risk scores (PRS) can further stratify individuals by risk across a range of diseases
Super excited to share our work this morning in Cologne! Lots of great discussion on combining genomics and proteomics for discovery and prediction
Super excited to share our new phenome-wide comparison of polygenic and proteomic risk scores in 40,000 people. We find proteins generally outpredict genetics for disease incidence, but polygenic prediction remains important in heritable diseases. medrxiv.org/content/10.1101/2025.07.10.25331242v1
Leena Peltonen School of Human Genetics in full-swing!
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Jakob Woerner
Jakob Woerner
Jakob Woerner
Jakob Woerner
Andrea Ganna
#IGES2025 Jakob Woerner
@jakobwoerner.bsky.social brilliantly outlines tradeoffs btw proteomics scores & polygenic scores in incident disease prediction. Lots of hints from his paper 👇
www.medrxiv.org/content/10.1...
Plasma proteins capture dynamic physiological processes and may offer more immediate insight into disease risk than static genetic predictors. We evaluated the predictive utility of proteomic risk sco...
