Our case report of a patient developing drug-induced systemic sclerosis after bleomycin exposure – still showing antibodies after 5 years. Nicely done Philipp 🎉 #rheumsky
authors.elsevier.com/sd/article/S...
Lennard Ostendorf
Immunological Changes:
* Mature plasma cell depleted from peripheral blood
* CD38+ T cells vanish from the blood, but their clonal frequencies are unchanged > lose CD38, show reduced dysfunction-associated transcriptional profile
* NK cells are depleted, otherwise stable cell counts
5/
Results – Primary Endpoint:
The primary endpoint (dsDNA antibody reduction at week 12) was met with a median dsDNA of 166.3 IU/ml at baseline to 61.1 IU/ml at week 12.
Vaccine-induced tetanus toxoid antibodies and total IgG were similarly reduced.
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Join us at Charité University and the IMPRS-IDI Graduate Program in Berlin to unravel NK cell clonality and memory! We are looking for motivated PhD candidates who are passionate about immunology. @romagnanilab.bsky.social
@timorckert.bsky.social
Apply now 👉 www.imprs-idi.org/home/
10 patients with refractory SLE (cSLEDAI > 3, failure of 2+ immunosuppressants) treated with 1800mg daratumumab (+dexamethasone for injection reaction prevention) 1/week for 8 weeks.
Primary EP: reduction in dsDNA antibodies at week 12
Secondary EP: clinical effect, safety, immunology
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Results Efficacy
* median SLEDAI dropped from 12 to 4 at week 12
* SRI-4 of 100% at week 12 (not other timepoints)
* at week 36 (last visit) SRI-4 still 70%, median SLEDAI still 4, 3 flares
Safety:
* 5/10 patients had IgG < 5g/l triggering IVIG repletion
* no severe AEs/infections occured
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Lennard Ostendorf
Lennard Ostendorf
Lennard Ostendorf
Our paper on the second Berlin patient came out in Nature today and I’m really happy we can share this story on World AIDS Day. I want to thank everyone on the team and all co-authors for their work over the years.
www.nature.com/articles/s41...
Looking for a #PhD project in #+immunology? The @romagnanilab.bsky.social offers two fully funded projects “Dissecting the Molecular Pathways of NK Cell Clonality” & “Dissecting the Molecular Pathways of NK Cell Memory“.
Apply by Dec 10 👉 www.mpiib-berlin.mpg.de/1947490/rese...
