First first-author paper out! 🎉
We show that the classically repressive mark H3K27me3 can be linked to active transcription through a newly identified reader complex 🤯
Really grateful to everyone involved in this project during my PhD!
Thread below 👇
Our latest publication is now out at Genome Biology!
link.springer.com/article/10.1...
We uncover a unique association between a H3K27me3 reader complex and active transcription.
A thread with our key findings: (1/8)
#TEsky #Polycomb #transcription #smallRNAs
Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...