First first-author paper out! 🎉
We show that the classically repressive mark H3K27me3 can be linked to active transcription through a newly identified reader complex 🤯
Really grateful to everyone involved in this project during my PhD!
Thread below 👇
now published at BMC Biology!
rdcu.be/fdITD
#ResultatScientifique🔎|Activer pour mieux réprimer ? Chez la paramécie, la transcription aide à verrouiller le génome contre les éléments mobiles🧬
✍️ @sandraduharcourt.bsky.social
📕 Genome Biology
▶️ buff.ly/RgSZhfQ
🤝 @ijmonod.bsky.social @upcite.bsky.social @cnrs-idf-villejuif.bsky.social @cnrs.fr
There are Science papers and then there are *I just dropped and shattered my mug of coffee Usual Suspects style* Science papers www.science.org/doi/10.1126/...
Germ cells have their own versions of core transcription factors and fertility depends on them.
We're hiring a PhD student to figure out how! 📢
Fly genetics + proteomics + genomics. Fully funded.
Aarhus University 🇩🇰
Deadline May 1 👇
Please share with anyone who might be interested!
Really happy to share that our preprint is now published in @narjournal.bsky.social! 🎉
Excited to share our new preprint exploring how Paramecium achieves diverse flow functions, i.e. feeding and swimming, simultaneously. This work was spearheaded by our ExM expert, PhD student Daphne Laan @daphnelaan.bsky.social :
www.biorxiv.org/content/10.6...
CNRS Biologie
Our work on chromatin evolution in brown algae is finally out!
This is also my first "co-first author" paper!! I’m excited to share what we found 👇
✍️ The @sandraduharcourt.bsky.social Lab published a new article
📖 Genome Biology
📃 A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium
🔗 link.springer.com/article/10.1...
Capolavoro 🎨 alert 🚨! What is the role of gene body methylation in invertebrates? Despite extensive speculation linking it to plasticity and environmental responses, its mechanistic effects and heritability remain unclear. Our take out in @natecoevo.nature.com: www.nature.com/articles/s41... 1/
phd.nat.au.dk
Thomas Balan
Excited to share our new preprint on BioRxiv!
A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1...
1/5
Abstract. Prokaryotes and eukaryotes use diverse strategies to cope with invading mobile genetic elements, including programmed DNA elimination (PDE). In t
Experiments in the cnidarian Nematostella vectensis show a role of gene body methylation in transposable element suppression and that epigenetic inheritance is constrained by chromatin context and tra...
Background. Paramecia belong to the ciliate phylum of unicellular eukaryotes characterized by nuclear dimorphism. A diploid germline micronucleus (MIC) transmits genetic information across sexual gene...
🚨 Excited to share my first preprint on bioRxiv! 🎓 We uncover a non-canonical role of condensin I, beyond chromosome segregation 🧬
This work is the fruit of a collaboration between the @sandraduharcourt.bsky.social & @betermieri2bc.bsky.social labs!
➡️ doi.org/10.1101/2025...
Our latest publication is now out at Genome Biology!
link.springer.com/article/10.1...
We uncover a unique association between a H3K27me3 reader complex and active transcription.
A thread with our key findings: (1/8)
#TEsky #Polycomb #transcription #smallRNAs
Our latest publication is now out at Genome Biology!
link.springer.com/article/10.1...
We uncover a unique association between a H3K27me3 reader complex and active transcription.
A thread with our key findings: (1/8)
#TEsky #Polycomb #transcription #smallRNAs
Prokaryotes and eukaryotes use diverse strategies to cope with invading mobile genetic elements, including programmed DNA elimination (PDE). In the ciliate Paramecium , elimination of transposable ele...
Chromatin plays a central role in gene regulation, but chromatin systems are only known for a few model species. This study analyses chromatin regulatory landscapes in brown algal lineages to elucidate their structural organization and evolution 🧪 www.nature.com/articles/s41...
Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...
Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...
Chromatin plays a central role in gene regulation, but chromatin systems are only known for a few model species. This study analyses chromatin regulatory landscapes in brown algal lineages to elucidat...
