Happy to see our recent work on SLC25A45 featured on the cover of @cp-cellmetabolism.bsky.social . Huge thanks to @yuyangliu.bsky.social for the design! @KivancBirsoy @rockefeller.edu
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and
SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as
a key mediator of mitochondrial impo...
dlvr.it
Artem Khan
Artem Khan
We then showed that knockout of Slc25a45 in mice leads to an impaired carnitine biosynthesis which becomes limiting under fasting conditions, compromising β-oxidation and energy homeostasis.
The cover depicts a GWAS Manhattan plot as a city skyline reflected onto a New York City-style subway metabolic map: organelles as boroughs, metabolites as stations, transporters as trains.
Biochemically, SLC25A45 is necessary for the transport of methylated basic amino acids, such as trimethyllysine, and also ADMA.
We found SLC25A45 was significantly associated with trimethyllysine, a byproduct of protein catabolism and a precursor for carnitine biosynthesis.
Thank you so much! I really appreciate your and Kevin's help!!
