Dual orexin receptor antagonism with lemborexant enhances #microglial clearance of β-#amyloid in mice
Ashish Sharma, Emiko Segawa, Xiaoying Chen...Erik S. Musiek @washumedicine.bsky.social #Sleep #AlzheimersDisease
link.springer.com/article/10.1...
We usually assume 🐜 ants 🐜 learn views when facing their goal, but our data shows that it is not necessarily the case!
We combined field experiments with a biologically constrained model to show how a two-stage neural circuit (MB -> CX) could allow this:
www.nature.com/articles/s41...
Excited to share our latest story! We found disentangled memory representations in the hippocampus that generalized across time and environments, despite the seemingly random drift and remapping of single cells. This code enabled the transfer of prior knowledge to solve new tasks
Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice - Djebari - The Journal of Physiology - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/full/10....
Excited to finally see this out! unexpected findings (and null results) can end exciting. One hidden nugget is that early before significant aggregation 3xtg mice sleep more by many measure. should have an answer to poss why coming soon!
journals.sagepub.com/doi/abs/10.1...
Early microglial response to amyloid plaques drives sleep loss in Alzheimer's disease - Constantino - 2026 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Check out this fascinating article aging.jmir.org/2026/1/e79224
Relationship between locus coeruleus and slow‐wave sleep in aging and Alzheimer's disease - Falgàs - 2026 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
The oscillatory biology of sleep: Linkage to dementia | Science www.science.org/doi/10.1126/...
Video
physoc.onlinelibrary.wiley.com
Background Sleep is an essential component of memory consolidation and waste clearance, including pathology associated with Alzheimer's disease (AD). Facil...
Background: Spatial navigation relies on egocentric and allocentric frames of reference, with the latter critically impaired in Alzheimer disease (AD) due to hippocampal involvement. Recent evidence s...
aging.jmir.org
This review offers a personal and historical perspective on spatial representations of the local environment in hippocampal regions CA1 and subiculum, as derived from extracellular electrophysiologic...
INTRODUCTION Sleep disruption, particularly loss of slow-wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus ...
alz-journals.onlinelibrary.wiley.com
During wakefulness, neuromodulators operate largely independently to support behavior and cognition. By contrast, sleep reorganizes their activity into a coordinated brain rhythm. During sleep, the ma...
INTRODUCTION Sleep disruption is an early feature of Alzheimer's disease (AD), but the cellular mechanisms linking amyloid pathology to sleep loss remain unclear. METHODS Electroencephalography/el...
