Oshio, Shiiba and colleagues show that HMOX2, which catalyses haem degradation, supplies haem-derived iron to mitochondria at ER–mitochondria contact sites in a process mediated by the mitochondrial u...
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Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.
Mitochondria and peroxisomes share functional links to maintain cell viability. Here, the authors reveal a mitochondria-driven quality control mechanism where mitochondrial E3 ligases clear mistargete...
The prion-like spread of tau from cell to cell in the central nervous system involves escape from the endolysosomal network, which is counteracted by the lysosomal repair activity of the ESCRT system....
Microtubule seeds are short, uncapped microtubule fragments that can reinitiate growth. Whether they exist in cells in vivo has not been demonstrated. In Drosophila neurons, many microtubules are dyna...
De Belly et al. show Rac induces membrane-tension-mediated mTORC2 activation to stimulate long-range Rho activation. Meanwhile, Rho-mediated contractility and blebbing at the opposite side of the cell...
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Cell Biology J-Club
Cell Biology J-Club
Lysosomal membrane damage triggers a multi-stage repair response essential for cellular homeostasis. Here we identify the oxysterol-binding protein-related protein ORP3 as a critical mediator of late-...
In eukaryotic cells, organelles communicate through membrane contact sites—specialized regions where their membranes come into close apposition without fusing. Among these, contacts between the endopl...
