Professor at University of Cologne, Germany, interested in cell death and cancer, nature enthusiast, secret musician, mum
Silvia von Karstedt
Loading...
Ever wondered how cellular #metabolism, #ROS, cellular confluence and #Ferroptosis are connected? Read our new study with theoretical physicist Johannes Berg @unicologne.bsky.social @cecad.bsky.social @uniklinikkoeln.bsky.social @dtg-cologne.bsky.social
www.frontiersin.org/journals/cel...
@cecad.bsky.social
Silvia von Karstedt
Inflammation fuels one of the most aggressive forms of cancer www.idw-online.de/-DS52AA
What a nice way to end 2025: absence of caspase 8 in #sclc leads to neuronal-like reprogramming and promotes #metastasis via #necroptosis driven #inflammatory response. Congratulations to Ariadne and collaborateurs @unicologne.bsky.social @dtg-cologne.bsky.social !
www.nature.com/articles/s41...
A caspase 8 deletion #SCLC mouse model promotes a neuronal progenitor-like cell state and pre-tumoral immunosuppression triggered by #necroptosis that promotes metastasis @vonkarstedtlab.bsky.social
@unicologne.bsky.social
@dtg-cologne.bsky.social
@cecad.bsky.social
doi.org/10.1038/s414...
Happy to share an incredibly efficient collaboration with @gianmaria-liccardi.bsky.social
: Ibrutinib cooperates with #ferroptosis induction to kill #dlbcl
www.nature.com/articles/s41...
Silvia von Karstedt
Silvia von Karstedt
Cell Death Discovery - Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL)
New preprint from the lab! Close collaboration with Silvia von Karstedt @vonkarstedtlab.bsky.social and her lab. We find that #SCLC cells are strikingly dependent on exogenous cysteine #LungCancer #CancerMetabolism #Ferroptosis 🧵
biorxiv.org/content/10.64898/2026.03.27.714827v1
Silvia von Karstedt
⚕️Ein Team der Pathologie der Uniklinik Köln hat das agentenbasierte KI-System SPARK entwickelt. Es verknüpft mehrere spezialisierte Algorithmen zu einem koordinierten System, das eigenständig biologische Hypothesen generieren, verfeinern und in analytische Werkzeuge umsetzen kann.
➡️ uni.koeln/BSZ8B
The study titled “Functional synapses between neurons and small-cell lung cancer” was published in @nature.com 👇
www.nature.com/articles/s41...
#unicologne #uniklöln @cecad.bsky.social
#sclc #lungcancer #cancerresearch
Julien Sage
🫁 Was macht das kleinzellige Lungenkarzinom (SCLC) so aggressiv? Forscher unter Leitung von @vonkarstedtlab.bsky.social vom @cecad.bsky.social / @unicologne.bsky.social haben einen neuen Mechanismus entdeckt, der dem #Lungenkrebs bei seiner Ausbreitung im Körper hilft. #SCLC
