Very cool to see the power of de novo design applied to dye-labeling!
Absolutely stunning work: de novo designed miniproteins targeting GPCRs as potent agonists and antagonists.
This opens countless possibilities for programmable signaling, cleaner therapeutics, and faster drug discovery.
Protein design is coming for pharmacology. 🚀
doi.org/10.1038/s415...
Check out the birghtest star in the room: PinkyCaMP - the latest member to the red GECI family! Amazing work led by Olivia Masseck and a wonderful team! Proud to contribute
Tommaso Patriarchi
The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot doi.org/10.7554/eLif... Great work by @labouessemarie.bsky.social and her student Alina! Congrats
Tommaso Patriarchi
Hello #world, meet 1,000× Expansion Microscopy.
A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy.
Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us.
Story: www.biorxiv.org/content/10.6...
🚨Exiting new preprint from Lerner Lab postdoc AJ Miller-Hansen examining the thalamus as a physiological driver of local, acetylcholine-dependent dopamine release! 🚨
DA-ACh interactions have been 🔥but what’s really going on in vivo? We think we have some answers.
#neuroskyence🧪
Tommaso Patriarchi
Out today in @natneuro.nature.com
What started as a great discussion at an amazing meeting organized by @joaofoliveira.bsky.social culminated in our new Perspective on how #astrocyte functions operate across multiple spatial scales.
Read: rdcu.be/fk0B7
Full text: www.nature.com/articles/s41...
Tommaso Patriarchi
Neuropixels + Optogenetics = Neuropixels Opto
Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors.
Today in @natmethods.nature.com
doi.org/10.1038/s415...
Thanks to @wellcometrust.bsky.social, @alleninstitute.org, @hhmijanelia.bsky.social & team.
Within the nucleus accumbens shell, a spatially defined rostral subregion selectively modulates hedonic feeding, revealing functional heterogeneity in reward circuitry underlying food consumption.
Meet NovoTags, a new class of fluorescent imaging probes that combines AI-driven protein design from #HHMIInvestigator David Baker w/ ultra-bright dyes from Janelia’s Luke Lavis, enabling scientists to watch dozens of proteins inside a cell at once — something current tools can't do: bit.ly/4noBb06
Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum https://www.biorxiv.org/content/10.64898/2026.05.08.723861v1
