Group Leader @EMBL. We study the design principles of "early" animals using cnidarians.
Aissam Ikmi
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A press release on our latest work on shape diversity in cnidarians. @embl.org
Congratulations Guillaume #Salbreux and collaborator @aikmi.bsky.social groups for your latest publication in @cellcellpress.bsky.social: Deciphering #mechanical determinants of morphological #evolution @genevunige.bsky.social @sciencesunige.bsky.social #UNIGE
👉 www.cell.com/cell/fulltex...
21st century dev bio at its best! I can't help but point out that not one but two Bruker microscopes (Acquifer IM, MuVi) were used for gentle&long term time lapse imaging of developing Nematostella here. No need to mount your invertebrate (cnidaria, planaria, crustaceans), we can do the time lapse!
A comparative analysis of cnidarian larval morphogenesis combined with active surface
theory identifies a set of mesoscale mechanical modules that predict species-specific
shapes. Manipulating these m...
Now published. Congrats to Soham and all co-authors! www.science.org/doi/10.1126/....
@embl.org
Aissam Ikmi
Hello epithelia enthusiasts!
I’m @inesfournon.bsky.social and I study epithelial mechanics in sea anemones 🪼
Did you know epithelial cell extrusion had never been described outside bilaterian animals before? Well… not anymore 👀
Read ⬇️🧵1/9
Biology-UNIGE
Video
Really happy to share my PhD story about the regulation of developmental speed in the Drosophila eye 🪰😃👀, which is now published @embojournal.org:
link.springer.com/article/10.1...
Grateful to everyone who make this possible, particularly F. Schweisguth @pasteur.fr @devstempasteur.bsky.social
How do #sponges coordinate their bodies despite lacking neurons and true muscles?
We show that sponges use monoamines to control water flow in their canals — reminiscent of how adrenaline regulates blood vessels.
My PhD story, now on BioRxiv:
www.biorxiv.org/content/10.6...
#Evolution
Expansion microscopy of a loricate choanoflagellate, generated by Mylan Ansel in our lab 🤩
(yes, the lorica expands. No, we don't understand how either)
A fossil nervous system meets modern neurobiology.
We found that a living comb jelly preserves neural architecture remarkably similar to those inferred from Cambrian fossils over 500 million years old 🤩.
www.biorxiv.org/content/10.6...
We thought we were just studying mesoglea biogenesis…Turns out Nematostella has been hiding a sophisticated backup pressure valve! Work driven by the talented PhD student Soham Basu! @embl.org www.biorxiv.org/content/10.1...
A sea anemone looks very different from a coral, despite belonging to the same broad biological group.
A new study from EMBL researchers and their colleagues sheds new light on how diversity arises in body shapes in the animal world.
www.embl.org/news/science...
Video
We thought we were just studying mesoglea biogenesis…Turns out Nematostella has been hiding a sophisticated backup pressure valve! Work driven by the talented PhD student Soham Basu! @embl.org www.biorxiv.org/content/10.1...
Video
epithelial mechanics fan club
Roy Zang
Nisha Veits
Video
Aissam Ikmi
EMBL
Thibaut Brunet
Pawel Burkhardt
Aissam Ikmi
Glad to see this out in its final form!
www.nature.com/articles/s41...
What changed since the preprint? Wonderful experiments disentangling the effect of receptor binding vs tissue porosity on Nodal diffusion, plus one of the smoothest review experiences! Thanks @natcellbio.nature.com & reviewers 🙏
Autorino et al. report a feedback loop between Nodal signalling and tissue phase transitions in zebrafish embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which l...
Here our latest work on how morphogens trigger tissue phase transitions to tune their own length-scales and time-scales - An exciting collaboration with @zhvas.bsky.social @dianakhorom.bsky.social Bernat Corominas-Murtra and heroic experiments by the incredible @cami-autorino.bsky.social @embl.org
Nicoletta Petridou
🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨
“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶
🔗 www.biorxiv.org/content/10.1...
#devbio #biophysics
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