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🧠PhD student at Mayo Clinic
Shanon Rego









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Bluesky plant people! My patio has potential…right now it’s just hot and sad :/ What would you add to bring it to life? #PlantsofBluesky #PatioPlants #GardeningInspiration #SmallSpaceGardening
11mo
Shanon Rego
Seeing my mentees thrive brings me, by far, much more joy than personal success! Huge congrats on your F31 NOA, Lupe!!! Let it be the first of many more achievements in 2026! 🎉🎊🍾 @sanchezlulu.bsky.social
4mo
Proud and very excited to be part of this publication (and this team ofc)🤓🧠! APOE4 impacts BAMs, meningeal immunity + lymphatics, and neuroinflammation differently in females vs. males, across mouse models and human data!
🚨 Our search for a postdoctoral researcher is still on! Contact me if you feel passionate about investigating neuroimmune mechanisms in neurodegenerative disorders. Candidates should have proven experience with rodent models of neurodegenerative disorders.
2mo
3mo
Shanon Rego
Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉 authors.elsevier.com/a/1l7l75FFzL...
Online now: Interleukin-34-dependent perivascular macrophages promote vascular function in the brain
Celebrating the 1st successful postdoctoral fellowship application from the lab! Liliana (@lilianacorreia.bsky.social) was awarded the NACC & @alzassociation.bsky.social New Investigator Award! On top of doing fantastic research, Lili is also an amazing colleague! We are all very proud of her! 😁🎉🍾🥂
May 20, 2025
May 1, 2025
9mo
The Da Mesquita lab at Mayo Clinic (www.mayo.edu/research/lab...) is looking for a postdoctoral researcher to work on projects investigating the role(s) of the meningeal lymphatic vasculature in models of neurodegenerative diseases. Please spread the word and contact me in case you are interested! 😃
Yet another amazing annual Mayo Clinic Neuroscience Departmental Retreat! Tons of exciting new research avenues and scientific breakthroughs! 😁🧠🔬🤓
The Da Mesquita Lab turned 5! Kudos to all present & past members! @lilianacorreia.bsky.social @shanonrego.bsky.social @sanchezlulu.bsky.social Virginia, Patty, Parul, Rae, Megan, Nicole & Sofia 🤩😍 It is your creativity, intelligence & hard work that make it all worth it. Here’s to another 5!!! 🎉🍾🥂
Sandro Da Mesquita
Sandro Da Mesquita
Sandro Da Mesquita
Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition: Neuron www.cell.com/neuron/fullt...
3mo
11mo
9mo
Sandro Da Mesquita
2mo
The Da Mesquita lab at Mayo Clinic (www.mayo.edu/research/lab...) is looking for a postdoctoral researcher to work on projects investigating the role(s) of the meningeal lymphatic vasculature in models of neurodegenerative diseases. Please spread the word and contact me in case you are interested! 😃
www.mayo.edu
Immunity
authors.elsevier.com
3mo
Delivanoglou et al. show that expression of APOE4, a risk factor for Alzheimer’s disease, leads to sexually dimorphic lymphatic and inflammatory responses in mice and humans alike. Suppressing APOE4-i...
www.cell.com
Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition
Sandro Da Mesquita
Sandro Da Mesquita
Sandro Da Mesquita
Sandro Da Mesquita
www.mayo.edu
Sandro Da Mesquita
The niche signals critical for the homeostasis and functions of the brain border-associated macrophages (BAMs) are not well understood. Van Hove et al. demonstrate that BAMs require IL-34 derived from mural cells and perivascular fibroblasts for their maintenance in adulthood. They show that BAMs are required to promote normal vascular function in the brain.
Interleukin-34-dependent perivascular macrophages promote vascular function in the brain
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