Programme Leader @malaghan.bsky.social & Associate Group Leader @babrahaminst.bsky.social, working on germinal centres, vaccines and tertiary lymphoid structures.
Michelle Linterman
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The GCs contracted, because of the lack of Tfh cells to support ongoing B cell proliferation, but then recovered when Tfh cells repopulated the GC. Resulting normal output and affinity maturation.
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Michelle Linterman
Victorian Infection and Immunity Network
Thanks for highlighting our work 🙏
Project led by Louise Webb @babrahaminst.bsky.social
Ever wondered what happens if you remove Tfh cells from established germinal centres?
Thank you Fiamma. So good to be at LUMC and the NVVI this week. Great science, and great company!
Our workflow to image and analyse germinal centres using a 50-plex cyclic staining protocol now out. Work led by Isabel San Martín Molina & Edith Marcial Juárez with @babrahaminst.bsky.social imaging facility scientists Simon Walker & Hanneke Okkenhaug.
onlinelibrary.wiley.com/doi/10.1002/...
Work led by Louise Webb now out www.science.org/doi/10.1126/...
A huge team effort: Helena Carslaw, Jess James,
@emae-watson.bsky.social, Silvia Innocentin, Jayalini Assalaarachchi, Sigrid Fra-Bido, Isabel San Martín Molina, @smguillaume.bsky.social , Sam Woolliscroft, Alice Burton & Grant Kennedy
Great to have this out, and such a pleasure to work together. @smguillaume.bsky.social @cristianbeccaria.bsky.social @iannaconelab.bsky.social
Michelle Linterman
Michelle Linterman
Michelle Linterman
Michelle Linterman
Michelle Linterman
Michelle Linterman
However, Tfh cells did not come back in full numbers, which left a hole in the memory T cell pool, resulting in smaller recall germinal centres upon rechallenge.
Michelle Linterman
We did. We wanted to disentangle the role of Tfh cells in GC formation from their ongoing maintenance, so we used a Il21cre iDTR approach to delete Tfh cells from established GCs. Our hypothesis was that the GC would collapse, but it was surprisingly resilient.
