Happy to see this massive collaboration out covering 12 different cohorts including almost 3,000 cognitively unimpaired individuals.
Plasma p-tau217 can be used to detect preclinical Alzheimer’s, but positive predictive values increase if +ve results are confirmed with CSF or PET
Gemma Salvadó
🚨Paper alert🚨
New publication in JAMA Neurology led by @gsalvado.bsky.social. In a multicentric study, we examined the clinical utility to assess preclinical #Alzheimer’s disease in cognitively unimpaired individuals.
jamanetwork.com/journals/jam...
A 🧵...
jamanetwork.com
This cohort study evaluates the use of plasma phosphorylated tau 217 in identifying preclinical Alzheimer disease in individuals with amyloid β pathology.