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Opinions are my own. Aspiring biophysicist & microscopist | Application Scientist at HHMI Janelia's AIC | MS/PhD UNC Physics
Chad Hobson









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I spy some light sheet microscopy at air-liquid interface πŸ‘€. Thanks for adding it to the list! www.biorxiv.org/content/10.6...
#FluorescenceFriday again, this time looking at mitochondria in two cells inside of a spheroid model. Imaged on our MOSAIC with adaptive optics + LLSM. This AIC project was done with Marguerite Blignaut's group at Stellenbosch University.
✨ We are looking forward to hosting Isabel Espinosa Medina of HHMI Janelia Research Campus at #2026SDB in Las Vegas! Her work explores how the autonomic nervous system affects the development and homeostasis of different organs like the pancreas. πŸ”¬ ✨#devbio
How does an orbiting spherical tissue suddenly break symmetry and sprout invasive strands? We can predict this behavior from the initial morphology! Hi, I’m @jiwon-kim.bsky.social from @ianywonglab.bsky.social.
It is finally out there in published form. πŸŽ‰ #MicroSplit (with an π•Š) #Microscopy πŸ”¬ #AI πŸ€– www.nature.com/articles/s41... And no paywall... so... enjoy the read! πŸ’Έ πŸ‘‹ This is where the post could end... but I will have to go on for a bit below... πŸ˜‰ 🧡
Leukocytes in a zebrafish larva moving towards a pipette filled with a chemoattractant (arachidonic acid). Credit to @niethammerlab.bsky.social @mskcancercenter.bsky.social. #ZebrafishZunday πŸ§ͺ
PinkyCaMP: a red genetically encoded calcium indicator with improved brightness and stability. @massecklab.bsky.social www.nature.com/articles/s41...
The Krendel lab has been working investigating Myo1e/f’s involvement in cell eating. Here’s a fun video of our work collected with @aicjanelia.bsky.social. Thanks a ton for helping us with this and the amazing #LightSheet imaging! Take a look at our work: www.biorxiv.org/content/10.6...
Happy #FluorescenceFriday, here is a macrophage engulfing a deformable particle imaged on our LLSM. This project from Mira Krendel's lab and the @aicjanelia.bsky.social just came out as a preprint today! www.biorxiv.org/content/10.6...
www.nature.com/articles/s41...
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PinkyCaMP is a red genetically encoded calcium indicator with improved brightness and photostability. Derived from mScarlet, it does not exhibit photoswitching upon blue light illumination and is ther...
PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities - Nature Methods
www.nature.com
Chad Hobson
Chad Hobson
Society for Developmental Biology
Zebrafish Rock!
Nature Methods
Yoseph Loyd
Chad Hobson
Florian Jug
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific diff...
www.nature.com
Video
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
epithelial mechanics fan club
Kurianlab
www.biorxiv.org
Our latest preprint list is now up on FocalPlane. Here, we focus on new tools and techniques in imaging. Let us know if you have any recommendations to add to our list. focalplane.biologists.com/2026/05/15/m...
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FocalPlane
Microscopy preprints – new tools and techniques in imaging - News
focalplane.biologists.com
Microscopy preprints – new tools and techniques in imaging - FocalPlane