Director of research CNRS at MMSB (C. Lesterlin/tacc team) interested in cellular and molecular mechanism of horizontal gene transfer
https://mmsb.cnrs.fr/equipe/transfert-d-adn-entre-cellules-bacteriennes/
Sarah Bigot
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Excited to share this new paper from the lab:
academic.oup.com/ismej/articl...!
See thread below
🧬 The kick-off meeting of the Erasmus+ Blended Intensive Programme “Microbes in Focus” took place on May 18th, 2026, with all selected students attending.
This international programme focuses on modern molecular microbiology, microbial genetics, and the study of microorganisms. 🧵👇
Excited to share our new paper out today in @science.org 🎉
We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩
Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/
#microsky #phagesky
www.science.org/doi/10.1126/...
Finally published. Many thanks to a wonderful collaborative team and scientific platforms!!! And thanks to editors and reviewers for enthusiasm and a great review.
www.nature.com/articles/s41...
I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...
My main postdoc paper is now out in @natureportfolio.nature.com npj Antimicrobials and Resistance! www.nature.com/articles/s44.... Using flow cytometry, we show that the nucleoside analogues azidothymidine, didanosine, stavudine, and trifluridine reduced transfer of AMR plasmids pCT and pKpQIL (1/3)
Here is it! Super new science from us on horizontal gene transfer & bact defense systems! Liyana OW YONG discovered the first-of-its-kind defense factor AbjA that triggers 'abortive conjugation' as a defense mechanism, by targeting the T4SS! How neat?! #MicroSky 1/7
www.biorxiv.org/content/10.6...
Final version of our last paper is out!
www.nature.com/articles/s41...
Are you investigating the biology of prokaryotic or eukaryotic cells? Are you looking for an excellent scientific environment to establish and lead your own research team? The I2BC is your place and a new call for team leaders is now open.
More info👇Deadline 22nd April
@i2bcparissaclay.bsky.social
And the preprint is out! www.biorxiv.org/content/10.6...
We compared plasmid conjugation in liquid and on solid across 13 AMR plasmids with different types of conjugative pili.
Abstract. Phage therapy offers an alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are promising the
www.science.org
Inactivation of chromosomal genes through plasmid-encoded IS elements is an extended mechanism of antimicrobial resistance evolution in bacteria.
An immunity-like system functions as a lysis control hub to promote gene transfer agent particle release from host bacterial cells, suggesting that bacterial immune systems may be co-opted to promote ...
