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by @jimpick.com
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Fantastic teamwork by Milica Mihailovic & Aleksandra Anisimova from the Karagöz lab @gekaragoz.bsky.social @maxperutzlabs.ac.at together with the @plantophagy.bsky.social lab — Another great collaboration 🙌 within our SFB program, published in @embojournal.org 🔗 link.springer.com/article/10.1...
2mo
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
link.springer.com
The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
🆕 publication! The @gekaragoz.bsky.social lab shows how cells clear stalled ribosomes at the ER, preventing harmful 'traffic jams' during protein synthesis🚦Their new @embojournal.org study reveals how quality control and UFMylation team up to keep translation moving ➡️ tinyurl.com/2czj8fvp
2mo
Max Perutz Labs Vienna
SFB Targeted Protein Degradation