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by @jimpick.com
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by @atsui.org
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Really happy to see the work (doi.org/10.1038/s414...) published. Here, we show the full-length helical cryo-EM structure of p62/SQSTM1 and first cryo-ET visual of p62 positive structures inside the cell.
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The selective autophagy receptor p62/SQSTM1 is organized in a structured double helical filament in vitro, the cryo-electron tomographic images in ATG5 knockdown conditions reveal Ca-rich layers of p6...
doi.org
Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo - Nature Communications
Carsten Sachse