Professor of Tuberculosis Epidemiology @LSHTM - TB nerd
Rein Houben
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very nice two-punch set of papers led by @mjsaunder.bsky.social and @cfmcquaid.bsky.social. First fix the many issues with recent reviews of BMI and TB, and then follow it through on the consequences for the key PAF metrics. Undernutrition was, is and remains a key driver of global TB burden.
New comment:
Tuberculosis and undernutrition: improving estimates to reinforce the policy imperative
www.thelancet.com/journals/lan...
In this modeling study, Allison Portnoy and colleagues investigate the potential impact of reduced international donor funding on the household economic burden of tuberculosis in low- and middle-income countries 🧪 #MedSky #TB
plos.io/4ryyBFX
www.thelancet.com
Undernutrition is a key driver of the global tuberculosis epidemic, increasing the
risk of people developing tuberculosis disease and of poor outcomes in those who do.1
Each year, WHO publishes estima...
“Wow, I saw in the last GTB report undernutrition is much less important for TB than we previously thought” I hear you say…
Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our latest comment here: www.thelancet.com/journals/lan...
PLOS Medicine
Undernutrition is a key driver of the global tuberculosis epidemic, increasing the
risk of people developing tuberculosis disease and of poor outcomes in those who do.1
Each year, WHO publishes estima...
Very important and helpful study, getting after the gap left by CXR and symptom pre-screening in disease prevalence surveys. Congrats @tomscriba.bsky.social and team on getting this done and through the publishing process.
Matthew Saunders
Understanding patterns of #TB exposure and transmission is needed for targeted prevention strategies. In our latest pre-print, @petedodd24.bsky.social and I estimated the proportion of TB exposure to and transmission from sex and age groups for 177 countries.
bit.ly/4nbV492
1/📢 In our new publication, we estimate that in 2022, 134 million people worldwide had a recent Mycobacterium tuberculosis (Mtb) infection and were at high risk of progressing to TB disease. Read the full paper in PLOS Medicine (tinyurl.com/mtbinfection). #TBSky
“Wow, I saw in the last GTB report undernutrition is much less important for TB than we previously thought” I hear you say…
Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our latest comment here: www.thelancet.com/journals/lan...
When fluoroquinolone resistance status is unknown, empirical use of BPaLM (adding moxifloxacin to BPaL) is cost-effective as a replacement for BPaL even with high fluoroquinolone resistance levels! 🦠💊
doi.org/10.1371/jour...
Our framework that informed the @who.int TB & climate change policy brief out now in @lancetrespirmed.bsky.social, exploring the intersections and implications of climate change for the TB epidemic. Key message? TB should be considered a climate-sensitive disease
www.thelancet.com/journals/lan...
Rein Houben
Tuberculosis (TB) is a major public health concern and the leading infectious cause of mortality globally. The disease exhibits strong prevalence patterns by age and sex, but the implications of these...
In a modelling study, Allison Portnoy and colleagues investigate the potential impact of reduced international donor funding on the household economic burden of Tuberculosis in low- and middle-income ...
Undernutrition is a key driver of the global tuberculosis epidemic, increasing the
risk of people developing tuberculosis disease and of poor outcomes in those who do.1
Each year, WHO publishes estima...
The WHO recommends the bedaquiline, pretomanid, and linezolid (BPaL) regimen with the additional fluoroquinolone antibiotic moxifloxacin (BPaLM) for initial treatment of multidrug- or rifampicin-resis...
Climate change is likely to exacerbate a range of determinants that drive tuberculosis,
the world's leading cause of death from a single infectious agent. However, tuberculosis
is often neglected in w...
Alvaro Schwalb and colleagues conducted a mathematical modelling study to estimate the global burden of viable Mycobacterium tuberculosis--that which can cause disease and be transmitted--to help guid...
More than half of tuberculosis cases detected by community prevalence surveys are classified as asymptomatic. We evaluated yield of symptom and chest …
