Loves stories. Behavioral Neurobiologist. Dopamine. Science. Technology. Reason. Photography. Baking. Films. Roger's Pink Floyd.
Assistant Professor of Psychology, UW-Madison
http://mohebi-associates.org/
Ali Mohebi
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This was a crazy, fun long-term project spearheaded by Clayton Barnes, with collaborators Felipe Cini and Peng Xu. Some bits started at @mblscience.bsky.social in the fabulous @nsb-mbl.bsky.social course! Biorxiv preprint here:
doi.org/10.64898/202...
Thrilled to share our work out in @nature.com today! Linking flexibility modeling, single-cell imaging, and targeted optogenetics allowed us to characterize how some prefrontal neurons, and mPFC-VTA neurons in particular, drive contingency degradation behavior.
www.nature.com/articles/s41...
Really pleased that this work with @dudman.bsky.social is now out in Neuron: A global dopaminergic learning rate enables adaptive foraging across many options
Yes please. Less is more...
One of my favorite neuroscience stories of 2025-2026. Glad to see it published for us enthusiasts to dig!
::Howard Fields:: I cherish the chance I had to interact and explore brain facts together, spiced with your existential questions!
Your smile, insight, and kindness touched everyone and transcended, and I will treasure the memories. Until we meet again: you need to see our hot new dataset...
Cool new work from @dudman.bsky.social and @fluketc.bsky.social Reward magnitude determines reinforcement learning efficiency: www.science.org/doi/10.1126/...
Really excited to see this in print!
Postdoc position available at postlab.psych.wisc.edu. Pls send cv to [email protected]
I wish Ilya had shown up. I wanted to ask him if he still cares about science as a public institution, and why he and his fellow captains of industry aren’t speaking up as the government is dismantling US science. Why do they think they don’t need us? >>
Jess Cardin
Madelyn Hjort
Standard animal learning studies minimize individual reward magnitudes to maximize the repetitions of reinforced behaviors. We investigated how reward magnitude influences initial learning across five...
Our interests in human memory and cognition encompass the cognitive and neural basis of working memory, attention, control, and consciousness.News Madison Symposium on Memory & Control. On 30 May 202...
This work provides a mechanistic understanding of how certain prefrontal circuits in the rodent brain permit flexibility to selectively stop learned behaviours through interactions with core subcortic...
www.nature.com
Brain activity and cognition exhibit state-dependent fluctuations that may reflect the influence of neuromodulatory systems, including norepinephrine (NE). Although the activity of noradrenergic neurons is strongly coupled to sleep-wake cycles and pupil dynamics, suggesting a global arousal signal, recent evidence suggests potentially modular partitioning of these cells. In addition, it is unclear whether different neuromodulatory signals exhibit distinct spatiotemporal patterns. We performed simultaneous, dual color mesoscopic imaging of either NE and calcium or NE and acetylcholine (ACh) signals across the neocortex, along with high-density electrophysiology, to investigate the relationship between NE release and neural activity. We find that the pattern of cortical NE signaling varies with behavioral state and is associated with enhanced functional connectivity. Simultaneous imaging of NE and ACh reveals spatiotemporally dynamic coupling between signals. Finally, NE signaling and functional connectivity are disrupted by sleep deprivation. Overall, our findings demonstrate that NE provides a multimodal signal that links transitions in behavioral state to cortical network interactions. ### Competing Interest Statement The authors have declared no competing interest. National Eye Institute, R01EY022951, R21EY036254, EY026878 National Institute of Mental Health, R01MH113852 National Institute on Aging, R21AG087186 National Institute of Neurological Disorders and Stroke, https://ror.org/01s5ya894, F31 NS129354 McKnight Foundation, https://ror.org/003ghvj67, Scholar Award
