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Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons
Our work on cAMP-dependent mechanisms in area postrema that mediate Semaglutide-induced weight loss in mice is out in final form. I learned a lot from this study and the effort of the team, especially Claire Gao who led the work, was inspiring. I hope it can stimulate new directions. rdcu.be/fj8Eu
Nature Metabolism - Semaglutide-induced weight loss is shown to depend on Gs-coupled signalling in GLP1R-expressing hindbrain neurons, with a critical role for cAMP in mediating neuronal activation...
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Andrew Lutas