(5/5) Why it matters: In vivo ablation of NVP-associated programs remodels the tumor and significantly extends survival. These studies move us from descriptive atlases to a mechanistic, targetable understanding of tumor organization. Check them out!
(4/5) Next: Meet the NVP (Neurovascular Progenitor) 🧬. This rare population co-expresses neural and perivascular programs. Using patient-derived lineage tracing, we proved NVPs can bridge the gap, giving rise to both neural and mesenchymal fates.
(1/5) How does glioblastoma maintain its immense heterogeneity? 🧠 Two new companion papers from the Bhaduri Lab @UCLA now on @bioRxiv offer a lineage-resolved view of GBM hierarchies. Let’s dive in! 🧵👇
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.1...
(3/5) These relationships organize into reproducible "Tracks". By understanding these clonal architectures, we can design "hierarchy-informed" combination to disrupt the interactions that drive tumor growth.
(2/5) First up: CellTagging! We integrated DNA barcoding with scRNA-seq in 235k+ cells from 9 patient tumors. We found that GBM growth is sustained by multiple non-redundant progenitors, not just one dominant stem cell. #GBM #CancerResearch
🌡️ HOTT isn't just about temperature.
Human Organoid Tumor Transplantation (HOTT) is one of the models Dr. Bhaduri's lab (@bhadurilab.bsky.social) developed to understand how interactions with #glioblastoma tissue and immune cells contribute to therapy failure.
#Neuroskyence @dgsomucla.bsky.social
