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Patients with #HeartFailure showed increased myocardial fibroblast activation using [68Ga]FAPI-46 PET/MRI, with distinct patterns by cardiomyopathy etiology, highlighting activated fibroblasts as a potential therapeutic target. ja.ma/4e9mnzy
Diagnosis of #TransthyretinCardiacAmyloidosis was frequently delayed >6 months after #HeartFailure in Medicare beneficiaries, especially among women and those with aortic stenosis, coronary artery disease, diabetes, or hypertension. ja.ma/4gisDpV
Supplementation with #Menaquinone7 for 2 years modestly slowed progression of #CoronaryArteryCalcification in patients with coronary artery disease, with no major adverse effects.
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Among #Medicare beneficiaries, women undergoing #TAVI experienced higher periprocedural complications and mortality but modestly better long-term survival vs men, with their proportion among TAVI recipients declining over time. ja.ma/3S80WpN
Among US veterans with #HeartFailure with reduced ejection fraction, fewer than one-quarter achieved quadruple guideline-directed medical therapy within 2.9 years, and medication copays were associated with lower rates of therapy achievement. ja.ma/3Qk1Tuv
Quadruple guideline-directed medical therapy in #HeartFailure with reduced ejection fraction was projected to offset hospitalization costs by nearly $10 000 per patient-year, frequently yielding net health care savings.
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Among #Medicare beneficiaries, women undergoing #TAVI experienced higher periprocedural complications and mortality but modestly better long-term survival vs men, with their proportion among TAVI recipients declining over time. ja.ma/444KxoM
💬 Editorial: MK-7 supplementation modestly slowed #CoronaryArteryCalcification progression, but evidence is insufficient regarding clinical benefits or impact on cardiovascular events.
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Among patients with #Type2Diabetes and #ChronicKidneyDisease, finerenone reduced risks of cardiovascular and kidney events and promoted regression of #CKM syndrome regardless of baseline stage. ja.ma/43nDEie
Among patients with angina and nonobstructive coronary arteries, overlapping #ANOCA endotypes were common, and each additional endotype detected on coronary function testing was associated with incrementally worse angina burden.
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