+1 to perhaps not utopian relabeling the world, but gently moving to directly describing the mutation impact in biophysical terms as destabilizing, aggregation-inducing, interface-destroying, etc.; and the higher level phenotypes as a function of these protein qualities, not of mutations!
Leopold Parts
I wrote an essay. It’s about gain-of-function mutations. And penguins. Also ion channels, chihuahuas, the film Alien, recycled cardboard, and the Apollonian mind. Oh, and muffins.
Thanks to the editors of #GENETICS @genetics-gsa.bsky.social for letting me take some stylistic liberties. 1/2
