Team Leader & Independent Fellow at the @crg.eu
At the Repetitive DNA Biology (REPBIO) Lab, we leverage the latest technologies to decode nucleotide sequences for investigating how repetitive DNA shapes genome function and contributes to disease.
Bernardo Rodríguez Martín
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Are you a professor / group leader looking for a course to teach that would be extremely welcomed by graduate students & postdocs? Come train with us in how to teach the tools of the creative scientific process in our European train the trainer event in Heidelberg.
night-science.org/train-the-tr...
#TEsky
Don't miss the other excellent contributions in this volume, exploring the roles of TE in ageing, the nervous system, early development, and cutting-edge omics approaches for TE investigation. [5/5]
One aspect I particularly like about this review is its historical perspective. We trace how our understanding of TE in cancer has evolved over the past decades, highlighting the key discoveries that shaped the field. [3/5]
We also integrated data from published studies to map the landscape of somatic L1 mutagenesis across tumor types and stages of tumor evolution, provide a catalogue of reported source L1s, and document driver alterations caused by a variety of TE-mediated mechanisms. [4/5]
What happens when the cellular mechanisms that silence transposable elements (TE) break down? In this review, we discuss how loss of TE control in cancer can trigger extensive somatic mutagenesis, genomic instability, inflammation and other consequences. [2/5]
#Bioinformatics #Genomics #LongReads #Hiring
Contribution from the REPBIO team at @crg.eu (Layla Diaz, @jemilianosf.bsky.social, and myself) to the Volume 116 of Advances in Genetics, on Transposable Elements in Health and Disease, edited by @epiageing-lab.bsky.social
sciencedirect.com/science/chap... [1/5]
📢📢 Job opening between the Bioinformatics Unit and my group (REPBIO) at @crg.eu
Interested in contributing to our efforts to leverage long-read sequencing technologies for human genome research?
Join us in Barcelona:
recruitment.crg.eu/content/jobs...
Please repost😊
Transcription start sites are new mutational hotspots, according to a new study by the CRG's Donate Weghorn in Nature Communications. The mutations can be passed down to future generations and appear shortly after conception, in the first few rounds of cell division.
