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We investigated how ZAKα senses stalled and collided ribosomes in the ribotoxic stress response.
Huge thanks to members of @cgen2025.bsky.social and all excellent collaborators who contributed to this work.👏
Congratulations to everyone involved!🎉
Online Now: Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes Online now:
The ribotoxic stress response is activated upon sensing of impaired translation by the MAP3 kinase ZAKα. Vind et al. demonstrate how ZAKα surveils the translation process and interacts with elongating, stalled, and collided ribosomes. ZAKα activation depends on ribosome-templated sequestration of inhibitory domains, dimerization, and activation-loop autophosphorylation in trans.
