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In our new paper in the special issue at @jphysiol.bsky.social, we show that FGF21-glucagon signalling drives sex-specific effects on weight loss and glucose tolerance in obese mice, and uncover an unexpected FGF21-deficiency-driven susceptibility to obesity in females.
2mo
Christoffer Merrild
I am proud to have done this work alongside @johansenvbi.bsky.social under the supervision of Pablo Ranea-Robles and @clemmensenc.bsky.social at @cbmr.science, University of Copenhagen. Curious to learn more? Read it here: doi.org/10.1113/JP28...
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Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. ...
Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice
Christoffer Merrild