Celebrating 50 years of ysbl and structural biology in York, seeing all former colleagues including @cryingem.bsky.social and @poojag96.bsky.social And it was a perfect occasion for summarizing outcomes of my Wellcome fellowship. Thanks all for organizing!
Great work run by @emmajbanks.bsky.social and @tunglejic.bsky.social showing that the gta lytic system in caulobacter evolved from a phage antidefence system. It was fun to collect tomo of these at SLAC and segment them with Mai at YSBL. www.nature.com/articles/s41...
Was invited to give a talk about tomography at ccp4 summer school. The most important slide is done
You know exactly when your auto zlp f×cked things up and when you noticed and fixed it (at 5am).
My second visit to SLAC-Stanford to learn more about cryoET. Look at the size of that screen! This is going to be fun!
What about your Easter Monday? #cryoem #remote #SLAC
Same screen, three weeks later. At SLAC they sure know how to teach you to fib mill. Now, how to interpret the #tomo data?
Could an immune system control release of gene transfer agents? Contributed here with tomograms of Caulobacter (check the beautiful segmentations done by my PhD student Mai) showcasing how the cell envelope changes when the immune system is present vs absent.
We identified a new type of what seems to be a gene transfer agent in the most abundant gut microbe. Long read sequencing was the key here, as it showed suspiciously many 4kb and 8kb reads, which fits the smallest T=3 shrinked and T=3 regular capsids. And indeed, GTAs! www.nature.com/articles/s41...
An immunity-like system functions as a lysis control hub to promote gene transfer agent particle release from host bacterial cells, suggesting that bacterial immune systems may be co-opted to promote ...
We still have space for additional attendees, and we encourage you to share this invitation within your networks so others can benefit from the fantastic panel we have assembled for this edition. Better program than your favourite paid conference - just saying 😉
Pavol Bardy
Pavol Bardy
Here, the authors show that packaging of bacterial DNA by phage-like particles is widespread in the gut microbiome, with activity of gene transfer agents being prominent in Oscillospiraceae and Rumino...
1/ Excited to share our latest work on gene transfer agents (GTAs) in Caulobacter crescentus, led by Emma Banks in collaboration with Pavol Bardy and Mai Nguyen from York!!! See a brief thread below.
shorturl.at/o6S1w
The program for the 3rd MGE Workshop is now live! Check out this year's speakers using the link below.
The deadline for registration closes on Friday 30th May ⏰
We look forward to seeing you all in Southampton in a few weeks time!
#MGE #MGEWorkshop #Southampton
www.ukmgeworkshop.org
Bacteria have evolved a wide array of immune systems to detect and defend against external threats including mobile genetic elements (MGEs) such as bacteriophages, plasmids, and transposons. MGEs are ...
